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Inoltre, l'adesione di Appenzello ha influenzato le dinamiche economiche della regione. L'accesso ai mercati dei cantoni confinanti ha aperto nuove opportunità commerciali per gli agricoltori e gli artigiani locali. Occur i cantoni cattolici, nel 1586 l'Appenzello ruppe l'alleanza con la città riformata di Mulhouse, negandole il diritto di app